The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease. Cereb Cortex — Axonal and synaptic failure suppress the transfer of firing rate oscillations, synchrony and information during high frequency deep brain stimulation.
Neurobiol Dis. Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science —8. Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet —5. Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus.
Exp Brain Res. Effects of high-frequency stimulation on subthalamic neuronal activity in parkinsonian patients. Arch Neurol. Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations. Dynamic stereotypic responses of basal ganglia neurons to subthalamic nucleus high-frequency stimulation in the parkinsonian primate. Front Syst Neurosci. Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata.
Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease. Spontaneous and evoked activity of substantia nigra pars reticulata neurons during high-frequency stimulation of the subthalamic nucleus.
Neurotransmitter release from high-frequency stimulation of the subthalamic nucleus. J Neurosurg. Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. Chiken S, Nambu A. Disrupting neuronal transmission: mechanism of DBS? Nambu A, Chiken S. Mechanism of DBS: inhibition, excitation, or disruption?
In: Itakura T, editor. The globus pallidus, deep brain stimulation, and Parkinson's disease. Neuroscientist — Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease.
Deogaonkar M, Vitek JL. Globus Pallidus stimulation for Parkinson's disease. Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease. Nat Rev Neurol. Frontal lobe connectivity and network community characteristics are associated with the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease. Brain Topogr. Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease.
Brain —9. STN-stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection. Hum Brain Mapp. Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effects. Cortical and subcortical blood flow effects of subthalamic nucleus stimulation in PD.
Subthalamic nucleus stimulation improves parkinsonian gait via brainstem locomotor centers. Imaging gait disorders in parkinsonism: a review. J Neurol Neurosurg Psychiatry — Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease. Ann Neurol. Functional correlates of pallidal stimulation for Parkinson's disease. PET functional imaging of deep brain stimulation in movement disorders and psychiatry.
J Cereb Blood Flow Metab. Regional metabolic correlates of surgical outcome following unilateral pallidotomy for Parkinson's disease. Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's diseaseA PET study of resting-state glucose metabolism. Performing functional magnetic resonance imaging in patients with Parkinson's disease treated with deep brain stimulation.
Safety of MRI in patients with implanted deep brain stimulation devices. Neuroimage T53—7. Subthalamic nucleus deep brain stimulation induces motor network BOLD activation: use of a high precision MRI guided stereotactic system for nonhuman primates. Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus. Neuroimage —8. Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease.
Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease. Parkinson disease: pattern of functional MR imaging activation during deep brain stimulation of subthalamic nucleus—initial experience.
Radiology — Clinical and cerebral activity changes induced by subthalamic nucleus stimulation in advanced Parkinson's disease: a prospective case-control study. Clin Neurol Neurosurg. NeuroImage — Deep brain stimulation for Parkinson's disease: disrupting the disruption. Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. White matter involvement in idiopathic Parkinson disease: a diffusion tensor imaging study.
White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology —9. Microstructural changes in white matter associated with freezing of gait in Parkinson's disease.
Fiber tractography of the axonal pathways linking the basal ganglia and cerebellum in Parkinson disease: implications for targeting in deep brain stimulation. Tractography patterns of subthalamic nucleus deep brain stimulation. Subthalamic nucleus deep brain stimulation: basic concepts and novel perspectives. Probabilistic versus deterministic tractography for delineation of the cortico-subthalamic hyperdirect pathway in patients with Parkinson disease selected for deep brain stimulation.
Optimal target localization for ventroposterolateral pallidotomy: the role of imaging, impedance measurement, macrostimulation and microelectrode recording. Stereotact Funct Neurosurg. Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels. Brain Res Brain Res Rev. Primary sensorimotor cortex drives the common cortical network for gamma synchronization in voluntary hand movements.
Existing motor state is favored at the expense of new movement during 13—35 Hz oscillatory synchrony in the human corticospinal system. Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance.
Complexity of subthalamic 13—35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease. Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans.
Brown P. Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Curr Opin Neurobiol. Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease.
Subthalamic nucleus stimulation modulates motor cortex oscillatory activity in Parkinson's disease. Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease. Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa.
Movement related dynamics of subthalmo-cortical alpha connectivity in Parkinson's disease. Synchronized neural oscillations and the pathophysiology of Parkinson's disease. Curr Opin Neurol. Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease. Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings.
Klimesch W. Alpha-band oscillations, attention, and controlled access to stored information. Trends Cogn Sci. The interplay of cholinergic function, attention, and falls in Parkinson's disease. Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait. Parkinsonism Relat Disord. Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease.
Beudel M, Brown P. Adaptive deep brain stimulation in Parkinson's disease. Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.
Weinberger M, Dostrovsky JO. A basis for the pathological oscillations in basal ganglia: the crucial role of dopamine. Neuroreport —6.
Gamma oscillations in the hyperkinetic state detected with chronic human brain recordings in Parkinson's disease. Neural oscillator based control for pathological tremor suppression via functional electrical stimulation. Control Eng Pract. A direct relationship between oscillatory subthalamic nucleus—cortex coupling and rest tremor in Parkinson's disease.
A brain network model explaining tremor in Parkinson's disease. Multiple oscillators are causing parkinsonian and essential tremor. Synchrony of rest tremor in multiple limbs in Parkinson's disease: evidence for multiple oscillators. J Neural Transm Vienna — Cerebello-cortical network fingerprints differ among essential, Parkinson and mimicked tremors.
The cerebral oscillatory network of parkinsonian resting tremor. Oscillating central motor networks in pathological tremors and voluntary movements. What makes the difference? NeuroImage —9. The primate subthalamic nucleus. Coherence between cerebellar thalamus, cortex and muscle in man. Intermuscular coherence in Parkinson's disease: relationship to bradykinesia. Neuroreport — Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson's disease.
Cognitive stress reduces the effect of Levodopa on Parkinson's resting tremor. Lewitt PA. Levodopa therapy for Parkinson's disease: pharmacokinetics and pharmacodynamics. Klingelhoefer L, Reichmann H. Parkinson's disease as a multisystem disorder. Parkinson's: a syndrome rather than a disease? The heterogeneity of early Parkinson's disease: a cluster analysis on newly diagnosed untreated patients. Group PS. Pramipexole vs levodopa as initial treatment for Parkinson disease: a randomized controlled trial.
Parkinson Study Group. JAMA —8. A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates.
Kim HJ, Jeon B. How close are we to individualized medicine for Parkinson's disease? Olanow CW. Levodopa: effect on cell death and the natural history of Parkinson's disease.
The movement disorder society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease. Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa. Neuropsychopharmacology Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems.
Trends Neurosci. Fox SH. Non-dopaminergic treatments for motor control in Parkinson's disease. Drugs — Shih LC, Tarsy D. Deep brain stimulation for the treatment of atypical parkinsonism. Predictors of effective bilateral subthalamic nucleus stimulation for PD. Neurology —4. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex.
Sci Rep. Clinical predictive factors of subthalamic stimulation in Parkinson's disease. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial. Neurostimulation for Parkinson's disease with early motor complications. Deep Brain Stimulation for Parkinson's Disease. Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease.
DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry — Neurosurgery The subthalamic nucleus at 3.
Intraoperative microstimulation predicts outcome of postoperative macrostimulation in subthalamic nucleus deep brain stimulation for Parkinson's disease. Neuromodulation — Falowski S, Dierkes J. An analysis of the use of multichannel microelectrode recording during deep brain stimulation surgeries at a single center. Oper Neurosurg Hagerstown — Latest view on the mechanism of action of deep brain stimulation. Shifting from constant-voltage to constant-current in Parkinson's disease patients with chronic stimulation.
Neurol Sci. The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation. Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease.
About the Author Magdalena Kegel Magdalena is a writer with a passion for bridging the gap between the people performing research, and those who want or need to understand it. She writes about medical science and drug discovery. Tags DNA methylation , dyskinesia , epigenetics , L-dopa. View Forums. Recommended reading. November 3, Columns by Jo Gambosi. November 3, News by Mary Chapman. We use cookies to enhance your experience on our website. Levodopa-induced dyskinesia is related to indirect pathway medium spiny neuron excitotoxicity: a hypothesis based on an unexpected finding.
Parkinsons Dis. Karasawa, N. Production of specific antibody against L-DOPA and its ultrastructural localization of immunoreactivity in the house-shrew Suncus murinus lateral habenular nucleus. Kubo, T. Evidence for L-DOPA systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat.
Kulisevsky, J. Brain Pt 6 , — Leinartaite, L. Lloyd, K. Lopez, V. PLoS Biol. Marakaki, C. L-DOPA stimulates cortisol secretion through adrenocorticotropic hormone release in short children. Marsden, C. Masukawa, D. L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.
JCI Insight 2, Localization of ocular albinism-1 gene product GPR in the rat central nervous system. Maurice, P. Asymmetry of GPCR oligomers supports their functional relevance. Meyer, R. U S A , — Misu, Y. Is l-DOPA an endogenous neurotransmitter?
Is DOPA a neurotransmitter? Mitrano, D. Neuroscience , — Miyamae, T. Life Sci. Mons, N. Visualization of L-dihydroxyphenylalanine in rat brain by using specific antibodies. Muller, T. Levodopa induces synthesis of nerve growth factor and growth hormone in patients with Parkinson disease. Murakami, T. Murer, M. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.
Nagatsu, T. Neural Transm. Vienna , — Nakamura, S. Non-effective dose of exogenously applied L-DOPA itself stereoselectively potentiates postsynaptic D2 receptor—mediated locomotor activities of conscious rats.
Piccirillo, R. An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. Cell Sci. Poletti, M. Rascol, O. Schiaffino, M. Signaling pathways in melanosome biogenesis and pathology. Cell Biol. Ocular albinism: evidence for a defect in an intracellular signal transduction system.
Shimamura, M. L-3,4-Dihydroxyphenylalanine—induced c-Fos expression in the CNS under inhibition of central aromatic L-amino acid decarboxylase. Neuropharmacology 50, — Smith, T.
0コメント